恶性黑色素瘤误诊为隆突性皮肤纤维肉瘤分析
【摘要】 目的 探讨皮肤恶性黑色素瘤误诊的原因。方法 对1例皮肤恶性黑色素瘤误诊为隆突性皮肤纤维肉瘤的临床资料进行回顾性分析。结果 左下肢皮肤肿物的组织学以梭形细胞为主，呈车辐状排列，无明显的色素沉着，与隆突性皮肤纤维肉瘤极为相似，但是免疫组织化学染色结果为：瘤细胞S00、HMB45及MelanA阳性，诊断为皮肤恶性黑色素瘤。结论 恶性黑色素瘤的临床表现复杂，缺乏特异性，组织学表现多样，形态复杂，诊断时应详细了解病史，认真观察切片，加以辅助检查，以减少误诊。【关键词】
恶性黑色素瘤；误诊；隆突性皮肤纤维肉瘤；组织学；免疫组织化学
The clinical analysis of cutaneous m alignant melanoma misdiagnosed dermatofibrosarcoma protuberans sarcoma
WANG Xiaohong,GOU Xinming,ZHENG Yanxuan,et al.
Department of Pathology,The Fifth Affiliated Hospital of SunYatsen University,Zhuhai 519000,China
【Abstract】 Objective
To investigate misdiagnosis reasons of the cutaneous m alignant melanoma.Methods One case of cutaneous m alignant melanoma misdiagnosed as dermatofibrosarcoma protuberans sarcoma were retrospectively analyzed. Results The left lower extremity skin tumor histology to the main spindle cells, arranged like spokes were no obvious pigmentation, sarcoma and dermatofibrosarcoma protuberans were very similar, but the results of immunohistochemical staining: the tumor cells S 00, HMB45 and MelanA positive diagnosis of cutaneous m alignant melanoma. Conclusion The clinical manifestations of m alignant melanoma of the complex, the lack of specificity, histological features varied, complex patterns, diagnosis should learn more about history, careful observation of slices, to be supplemented by checks to reduce misdiagnosis. ......
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