2型糖尿病患者糖尿病肾病与血脂的相关性分析(1)
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【摘要】 目的 通过观察2型糖尿病患者尿微量白蛋白与血脂的相关性，探讨血脂异常与糖尿病肾病的关系。方法 选取48例2型糖尿病患者，根据尿mAlb/Cr结果分为无微量白蛋白尿组(DM组)及伴有微量白蛋白尿组(DN组)。检测甘油三酯 (TG)、总胆固醇 (TC)、高密度脂蛋白 (HDL)、低密度脂蛋白(LDL)等，观察各项指标与尿mAlb/Cr的关系。对照组20例。结果 对照组TG、TC、LDL与DN组比较，均明显降低 (P<0.05)，DM组TG、TC、LDL明显低于DN组 (P<0.05)。结论 2型糖尿病患者血脂异常是糖尿病肾病的重要危险因素之一。
【关键词】
2型糖尿病；尿微量白蛋白；血脂异常
Correlation of diabetic nephropathy with blood fat in patients with type 2 diabetes mellitus
ZHAO Jing, MING Hui, HUANG Haiquan. Department of Endocrine,Tongling peoples Hospital,Anhui 244000,China
【Abstract】 Objective To observe the correlation of urinary microalbumin with blood fat in patients with type 2 diabetes mellitus in order to explore the relationship between dyslipidemia and diabetic nephropathy. Methods Fortyeight patients with type 2 diabetes mellitus were enrolled, then diabetic patients were divided into DM group (without microalbuminuria) and DN group (with microalbuminuria) according to urinary albumin/creatinine ratio. The following factors were analyzed,such as triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and so on. Meanwhile, the relationship between such factors and urinary microalbumin was investigated. Twenty healthy people were selected as normal control group. Results Compared with DN group, TG, TC and LDL were signficanfly lower in normal control group (P<0.05).TG, TC and LDL were remarkably lower in DM group than those in DN group (P<0.05).Conclusion Dyslipidemia in type 2 diabetic patients may be an important risk factor that gives rise to diabetic nephropathy.
【Key words】
Type 2 diabetes mellitus； Urinary microalbumin； Dyslipidemia
作者单位：244000安徽省铜陵市人民医院内分泌科
糖尿病肾病(Diabetic nephropathy，DN)是糖尿病(diabetes mellitus DM)常见的慢性并发症之一，随着DM发病率增加，DN日益增多，其发病机制至今尚未完全明了。尿微量白蛋白(mALB)增高是糖尿病肾病(DN)最早期的生化表现,本文通过对2型糖尿病患者尿微量白蛋白与血脂的相关性进行分析,以探讨脂代谢紊乱与DN发生的联系。
1 资料与方法
1.1 一般资料 选择48例2型糖尿病(T2 dM)患者，均符合1999年WHO的诊断标准。排除感染、妊娠、外伤等应激情况，排除急性代谢紊乱如糖尿病酮症等 ......
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